Statistics
| Case | Control |
|---|---|
| 504 | 459690 |
Phenotype Definition
Inflammatory or noninflammatory diseases affecting the glomeruli of the nephron. [HPO:sdoelken]
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr11:98169925 | rs7115022 | - | G>T | 39 | 16418 | 26.34 | 2.869e-07 | 2.261 |
| chr6:69293224 | rs62416511 | - | T>C | 48 | 21435 | 26.33 | 2.877e-07 | 2.102 |
| chr5:129585039 | rs114252164 | - | C>T | 45 | 20047 | 26.06 | 3.302e-07 | 2.139 |
| chr1:66980066 | rs114638580 | - | G>A | 55 | 26418 | 25.51 | 4.398e-07 | 1.987 |
| chr1:241260342 | rs116679899 | RGS7 | C>G | 56 | 27327 | 25.04 | 5.613e-07 | 1.965 |
| chr2:128041692 | rs4150437 | ERCC3 | A>G | 89 | 49705 | 24.9 | 6.05e-07 | 1.728 |
| chr1:16525657 | rs148325785 | ARHGEF19 | A>G | 32 | 12943 | 23.77 | 1.084e-06 | 2.341 |
| chr11:44308495 | rs117882103 | ALX4 | C>T | 50 | 24150 | 22.93 | 1.683e-06 | 1.977 |
| chr5:130146777 | rs4334878 | - | C>G | 34 | 14352 | 22.8 | 1.794e-06 | 2.251 |
| chr11:98239793 | rs6589427 | - | A>G | 48 | 22994 | 22.26 | 2.376e-06 | 1.984 |
| chr15:81813286 | rs17338496 | - | C>T | 555 | 447098 | 22.01 | 2.707e-06 | 1.337 |
| chr11:44496303 | rs116899867 | - | G>C | 40 | 18180 | 21.77 | 3.067e-06 | 2.088 |
| chr23:107441100 | rs141943798 | COL4A6 | G>A | 29 | 13336 | 21.71 | 3.17e-06 | 2.358 |
| chr11:98191553 | rs12364117 | - | T>C | 45 | 21486 | 21.09 | 4.389e-06 | 1.987 |
| chr11:28970148 | rs80350147 | - | C>T | 43 | 20434 | 20.56 | 5.793e-06 | 2.0 |
| chr18:19173862 | rs72884755 | ESCO1 | G>A | 52 | 26294 | 20.41 | 6.252e-06 | 1.883 |
| chr8:11221539 | rs62488751 | - | C>G | 32 | 13784 | 20.13 | 7.222e-06 | 2.195 |
| chr1:16559719 | rs116323786 | CPLANE2 | G>A | 35 | 15638 | 20.07 | 7.481e-06 | 2.124 |
| chr7:3399315 | rs62437708 | SDK1 | C>T | 52 | 26446 | 20.06 | 7.514e-06 | 1.873 |
| chr16:85000701 | rs67648026 | - | A>G | 145 | 95310 | 19.86 | 8.351e-06 | 1.487 |
| chr11:98169925 | rs7115022 | - | G>T | 34 | 12793 | 28.87 | 7.743e-08 | 2.478 |
| chr6:31575276 | rs9348876 | - | C>T | 110 | 62572 | 26.73 | 2.337e-07 | 1.677 |
| chr2:128041692 | rs4150437 | ERCC3 | A>G | 88 | 48506 | 23.79 | 1.076e-06 | 1.713 |
| chr6:69293224 | rs62416511 | - | T>C | 47 | 21106 | 23.61 | 1.18e-06 | 2.039 |
| chr1:16525657 | rs148325785 | ARHGEF19 | A>G | 32 | 12810 | 23.19 | 1.467e-06 | 2.319 |
| chr11:98191553 | rs12364117 | - | T>C | 39 | 16813 | 23.18 | 1.477e-06 | 2.156 |
| chr6:31572927 | rs9378200 | - | T>C | 102 | 58838 | 23.13 | 1.515e-06 | 1.645 |
| chr6:31643522 | rs9378164 | - | G>A | 97 | 55497 | 22.95 | 1.663e-06 | 1.66 |
| chr18:70906826 | rs1039474 | - | A>G | 218 | 147804 | 22.67 | 1.922e-06 | 1.437 |
| chr11:44308495 | rs117882103 | ALX4 | C>T | 50 | 23816 | 22.5 | 2.102e-06 | 1.966 |
| chr23:107441100 | rs141943798 | COL4A6 | G>A | 29 | 12900 | 22.37 | 2.245e-06 | 2.389 |
| chr1:66980066 | rs114638580 | - | G>A | 53 | 25752 | 22.22 | 2.435e-06 | 1.923 |
| chr5:129585039 | rs114252164 | - | C>T | 43 | 19550 | 22.16 | 2.51e-06 | 2.052 |
| chr1:241260342 | rs116679899 | RGS7 | C>G | 54 | 26556 | 22.06 | 2.64e-06 | 1.909 |
| chr1:1030565 | rs6687776 | C1orf159 | C>T | 212 | 144811 | 21.44 | 3.646e-06 | 1.428 |
| chr15:81813286 | rs17338496 | - | C>T | 541 | 427807 | 21.29 | 3.957e-06 | 1.339 |
| chr18:19173862 | rs72884755 | ESCO1 | G>A | 52 | 25449 | 21.29 | 3.957e-06 | 1.909 |
| chr11:98239793 | rs6589427 | - | A>G | 42 | 19257 | 20.97 | 4.664e-06 | 2.03 |
| chr6:31628216 | rs28732157 | C6orf47 | C>T | 91 | 52492 | 20.69 | 5.411e-06 | 1.641 |
| chr10:44781374 | rs116884438 | - | T>C | 31 | 12827 | 20.6 | 5.655e-06 | 2.241 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr6:31575276 | rs9348876 | - | C>T | 110 | 1175 | 28.93 | 7.512e-08 | 1.751 |
| chr6:31572927 | rs9378200 | - | T>C | 102 | 1104 | 25.25 | 5.045e-07 | 1.718 |
| chr6:31643522 | rs9378164 | - | G>A | 97 | 1040 | 25.09 | 5.481e-07 | 1.736 |
| chr17:74105839 | rs12937183 | EXOC7 | T>C | 20 | 114 | 24.81 | 6.323e-07 | 3.171 |
| chr18:70906826 | rs1039474 | - | A>G | 218 | 2813 | 24.81 | 6.325e-07 | 1.481 |
| chr1:241260342 | rs116679899 | RGS7 | C>G | 54 | 487 | 24.37 | 7.946e-07 | 2.039 |
| chr4:76005892 | rs6534447 | - | G>T | 120 | 1376 | 23.8 | 1.069e-06 | 1.631 |
| chr10:44781374 | rs116884438 | - | T>C | 31 | 232 | 22.23 | 2.418e-06 | 2.426 |
| chr1:16525657 | rs148325785 | ARHGEF19 | A>G | 32 | 243 | 22.17 | 2.501e-06 | 2.39 |
| chr6:31628216 | rs28732157 | C6orf47 | C>T | 91 | 991 | 22.05 | 2.656e-06 | 1.703 |
| chr1:1030565 | rs6687776 | C1orf159 | C>T | 212 | 2790 | 21.93 | 2.831e-06 | 1.452 |
| chr11:98169925 | rs7115022 | - | G>T | 34 | 267 | 21.83 | 2.983e-06 | 2.317 |
| chr4:76032112 | rs76931926 | - | C>T | 147 | 1797 | 21.62 | 3.33e-06 | 1.534 |
| chr6:31669295 | rs2295663 | ABHD16A | A>G | 91 | 995 | 21.53 | 3.486e-06 | 1.692 |
| chr6:31583224 | rs28732150 | AIF1 | G>A | 91 | 996 | 21.37 | 3.782e-06 | 1.689 |
| chr18:19173862 | rs72884755 | ESCO1 | G>A | 52 | 483 | 21.23 | 4.065e-06 | 1.968 |
| chr6:31592064 | rs2280801 | PRRC2A | C>T | 91 | 1000 | 21.13 | 4.282e-06 | 1.684 |
| chr8:11221539 | rs62488751 | - | C>G | 32 | 248 | 21.11 | 4.338e-06 | 2.341 |
| chr3:131537596 | rs3914308 | CPNE4 | T>G | 136 | 1646 | 21.09 | 4.372e-06 | 1.547 |
| chr1:66980066 | rs114638580 | - | G>A | 53 | 499 | 20.76 | 5.204e-06 | 1.942 |
Associated Diseases ⓘ
| ID | Name | Top Correlation |
|---|---|---|
| ICD: N138 | Other obstructive and reflux uropathy | 2/20 |
| ICD: N139 | Obstructive and reflux uropathy, unspecified | 1/20 |
| ID | Name | Top Correlation |
|---|