Statistics
| Case | Control |
|---|---|
| 41376 | 418818 |
Phenotype Definition
An abnormality of fear/anxiety-related behavior, which may relate to either abnormally reduced fear/anxiety-related response or increased fear/anxiety-related response. [HPO:sdoelken]
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr2:26113913 | rs78404020 | - | A>G | 969 | 12848 | 66.02 | 4.456e-16 | 0.7623 |
| chr6:93667780 | rs9363020 | - | G>A | 825 | 11166 | 65.2 | 6.761e-16 | 0.747 |
| chr15:48426484 | rs1426654 | SLC24A5 | A>G | 2096 | 25430 | 63.99 | 1.252e-15 | 0.8321 |
| chr23:71651365 | rs12007867 | AL133500.1 | C>T | 734 | 9937 | 56.05 | 7.059e-14 | 0.7505 |
| chr5:33958959 | rs28777 | SLC45A2 | A>C | 4625 | 52367 | 54.47 | 1.581e-13 | 0.8902 |
| chr7:83498179 | rs35433560 | - | TG>T | 788 | 10462 | 53.9 | 2.114e-13 | 0.7621 |
| chr6:22050187 | rs1736507 | - | C>A | 1054 | 13459 | 53.41 | 2.702e-13 | 0.7908 |
| chr5:33951693 | rs16891982 | SLC45A2 | G>C | 5496 | 61562 | 53.37 | 2.762e-13 | 0.8992 |
| chr15:48392165 | rs1834640 | - | A>G | 2477 | 29147 | 52.07 | 5.353e-13 | 0.8581 |
| chr16:75787596 | rs74250922 | TERF2IP | A>G | 2528 | 29694 | 51.81 | 6.122e-13 | 0.8597 |
| chr7:22797207 | rs73276345 | - | A>G | 4698 | 52982 | 51.47 | 7.254e-13 | 0.8938 |
| chr23:71819691 | rs7054230 | PHKA1 | A>G | 1142 | 14461 | 51.03 | 9.111e-13 | 0.8017 |
| chr23:113179454 | rs72619782 | - | T>G | 965 | 12457 | 50.95 | 9.487e-13 | 0.7869 |
| chr23:75530806 | rs1604733 | - | T>C | 1692 | 20573 | 50.13 | 1.438e-12 | 0.8343 |
| chr1:54009583 | rs41363049 | GLIS1 | C>T | 939 | 12060 | 49.42 | 2.069e-12 | 0.7875 |
| chr1:169510139 | rs13306334 | F5 | G>A | 827 | 10781 | 49.3 | 2.192e-12 | 0.7758 |
| chr23:75663292 | rs6647232 | - | A>G | 1705 | 20686 | 48.65 | 3.065e-12 | 0.8371 |
| chr6:170242949 | rs9396958 | - | T>C | 1195 | 14919 | 48.43 | 3.424e-12 | 0.8103 |
| chr2:211717706 | rs12995612 | - | C>G | 1225 | 15247 | 48.4 | 3.474e-12 | 0.8124 |
| chr23:75004529 | rs1343879 | MAGEE2 | C>A | 1725 | 20859 | 47.98 | 4.316e-12 | 0.8389 |
| chr7:114223723 | rs1229761 | FOXP2 | A>C | 27039 | 282077 | 33.82 | 6.055e-09 | 0.9558 |
| chr9:127932402 | rs7852933 | PPP6C | G>A | 25005 | 261202 | 32.18 | 1.402e-08 | 0.956 |
| chr2:60500144 | rs10202231 | - | A>T | 38942 | 402584 | 29.05 | 7.043e-08 | 0.9614 |
| chr8:71368614 | rs12547808 | - | T>C | 25710 | 252727 | 28.74 | 8.269e-08 | 1.043 |
| chr7:114015707 | rs12705960 | FOXP2 | A>C | 40914 | 406218 | 28.41 | 9.81e-08 | 1.04 |
| chr3:84227826 | rs7639074 | - | G>T | 12348 | 119316 | 27.97 | 1.233e-07 | 1.056 |
| chr3:84424761 | rs9856889 | - | C>A | 12000 | 115895 | 27.96 | 1.239e-07 | 1.056 |
| chr9:127816147 | rs600310 | SCAI | T>C | 28198 | 293027 | 27.25 | 1.785e-07 | 0.9607 |
| chr6:396321 | rs12203592 | IRF4 | C>T | 18497 | 180418 | 26.86 | 2.183e-07 | 1.047 |
| chr11:113283459 | rs6277 | DRD2 | A>G | 37903 | 375975 | 26.78 | 2.277e-07 | 1.039 |
| chr8:71358298 | rs13253950 | - | G>T | 23372 | 229542 | 26.42 | 2.741e-07 | 1.043 |
| chr18:50683306 | rs4372758 | DCC | T>C | 36876 | 365512 | 26.3 | 2.916e-07 | 1.038 |
| chr9:81339569 | rs1757945 | - | A>G | 25439 | 264721 | 26.14 | 3.177e-07 | 0.9604 |
| chr2:60509080 | rs1553933 | - | T>C | 33378 | 345649 | 26.09 | 3.265e-07 | 0.9627 |
| chr7:117960973 | rs41943 | ANKRD7 | T>C | 34871 | 373805 | 26.02 | 3.372e-07 | 0.9613 |
| chr1:170641803 | rs502612 | PRRX1 | T>C | 39361 | 406074 | 25.41 | 4.634e-07 | 0.9638 |
| chr11:39698786 | rs11035405 | - | T>C | 23823 | 234292 | 25.01 | 5.717e-07 | 1.041 |
| chr18:50737358 | rs62100766 | DCC | G>T | 33349 | 329983 | 25.0 | 5.719e-07 | 1.038 |
| chr11:113268059 | rs11604671 | ANKK1 | G>A | 41303 | 425665 | 24.89 | 6.077e-07 | 0.9643 |
| chr6:33098569 | rs9277768 | - | C>T | 23905 | 235069 | 24.77 | 6.452e-07 | 1.041 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr3:85102758 | rs75141803 | CADM2 | T>C | 1338 | 1364 | 27.45 | 1.613e-07 | 0.8163 |
| chr6:57632547 | rs62411902 | - | C>T | 2756 | 1978 | 27.16 | 1.869e-07 | 1.168 |
| chr7:117960973 | rs41943 | ANKRD7 | T>C | 37984 | 33668 | 25.97 | 3.474e-07 | 0.9478 |
| chr1:46990044 | rs12408243 | - | G>T | 43089 | 35039 | 25.58 | 4.243e-07 | 1.052 |
| chr6:144529804 | rs12211395 | - | C>T | 3879 | 2873 | 24.57 | 7.154e-07 | 1.133 |
| chr1:47017706 | rs1258045 | - | T>G | 41881 | 35934 | 23.97 | 9.773e-07 | 0.9519 |
| chr6:58369084 | rs62464122 | - | C>T | 2764 | 2004 | 23.65 | 1.154e-06 | 1.156 |
| chr8:21578955 | rs79065192 | GFRA2 | C>T | 2057 | 1990 | 22.56 | 2.033e-06 | 0.8597 |
| chr23:75530806 | rs1604733 | - | T>C | 1692 | 1764 | 22.07 | 2.631e-06 | 0.8505 |
| chr6:58672808 | rs62411475 | - | T>A | 2533 | 1838 | 21.78 | 3.052e-06 | 1.156 |
| chr1:47055992 | rs956527 | MKNK1 | C>T | 42056 | 35940 | 21.43 | 3.67e-06 | 0.9546 |
| chr7:83498179 | rs35433560 | - | TG>T | 788 | 827 | 21.41 | 3.718e-06 | 0.7937 |
| chr5:163290591 | rs1489525 | - | A>G | 5467 | 4977 | 20.92 | 4.787e-06 | 0.9115 |
| chr6:62235412 | rs62424573 | - | C>A | 5108 | 3883 | 20.83 | 5.015e-06 | 1.105 |
| chr2:26113913 | rs78404020 | - | A>G | 969 | 992 | 20.75 | 5.238e-06 | 0.8133 |
| chr2:109756370 | rs6746925 | SH3RF3 | A>G | 9474 | 8430 | 20.57 | 5.743e-06 | 0.9305 |
| chr23:71651365 | rs12007867 | AL133500.1 | C>T | 734 | 822 | 20.57 | 5.748e-06 | 0.7935 |
| chr6:62275537 | rs76094498 | - | T>A | 1484 | 1032 | 20.56 | 5.789e-06 | 1.203 |
| chr23:71819691 | rs7054230 | PHKA1 | A>G | 1142 | 1223 | 20.55 | 5.82e-06 | 0.8286 |
| chr23:75663292 | rs6647232 | - | A>G | 1705 | 1768 | 20.42 | 6.229e-06 | 0.8561 |
| chr3:85102758 | rs75141803 | CADM2 | T>C | 1312 | 1342 | 27.29 | 1.751e-07 | 0.8152 |
| chr6:57632547 | rs62411902 | - | C>T | 2678 | 1941 | 23.92 | 1.002e-06 | 1.159 |
| chr6:144529804 | rs12211395 | - | C>T | 3419 | 2528 | 23.03 | 1.591e-06 | 1.137 |
| chr17:54426899 | rs12944442 | ANKFN1 | G>A | 12808 | 10132 | 21.5 | 3.536e-06 | 1.069 |
| chr7:117960973 | rs41943 | ANKRD7 | T>C | 34871 | 31006 | 21.44 | 3.646e-06 | 0.951 |
| chr7:111695096 | rs62474290 | DOCK4 | C>A | 3042 | 2861 | 21.37 | 3.794e-06 | 0.8845 |
| chr15:33160420 | rs117382859 | FMN1 | C>A | 1315 | 1315 | 21.34 | 3.849e-06 | 0.834 |
| chr1:46990044 | rs12408243 | - | G>T | 41698 | 34067 | 20.45 | 6.121e-06 | 1.048 |
| chr2:196866420 | rs6434811 | DNAH7 | T>C | 7248 | 5617 | 20.36 | 6.415e-06 | 1.087 |
| chr8:21578955 | rs79065192 | GFRA2 | C>T | 2005 | 1931 | 20.03 | 7.639e-06 | 0.8655 |
| chr6:32599999 | rs9272105 | HLA-DQA1 | G>A | 40140 | 34354 | 19.41 | 1.053e-05 | 0.9556 |
| chr6:58369084 | rs62464122 | - | C>T | 2644 | 1943 | 19.3 | 1.118e-05 | 1.142 |
| chr6:62235412 | rs62424573 | - | C>A | 4993 | 3814 | 19.24 | 1.153e-05 | 1.102 |
| chr6:32593507 | rs9271720 | - | G>A | 37945 | 32514 | 19.08 | 1.254e-05 | 0.9557 |
| chr12:8207076 | rs76295138 | FOXJ2 | C>T | 991 | 1005 | 18.89 | 1.387e-05 | 0.8224 |
| chr6:58672808 | rs62411475 | - | T>A | 2462 | 1806 | 18.84 | 1.421e-05 | 1.146 |
| chr5:163290591 | rs1489525 | - | A>G | 4759 | 4347 | 18.66 | 1.563e-05 | 0.9108 |
| chr7:158177699 | rs7455219 | PTPRN2 | A>C | 7533 | 6749 | 18.53 | 1.671e-05 | 0.927 |
| chr1:47017706 | rs1258045 | - | T>G | 38568 | 33101 | 18.42 | 1.769e-05 | 0.9565 |
| chr20:14931245 | rs181319 | MACROD2 | T>C | 18321 | 15960 | 18.35 | 1.835e-05 | 0.9486 |
Associated Diseases ⓘ
| ID | Name | Top Correlation |
|---|---|---|
| ICD: F101 | Harmful use | 4/20 |
| ICD: F121 | Harmful use | 1/20 |
| ICD: F171 | Harmful use | 1/20 |
| ICD: F32 | Depressive episode | 6/20 |
| ICD: F419 | Anxiety disorder, unspecified | 4/20 |