Statistics
| Case | Control |
|---|---|
| 11513 | 448681 |
Phenotype Definition
An abnormality of the plantar part of foot, that is of the soles of the feet. [HPO:probinson]
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr23:142717383 | rs73577386 | SLITRK4 | A>G | 297 | 7325 | 65.15 | 6.935e-16 | 1.612 |
| chr23:106146349 | rs5962774 | MORC4 | T>C | 399 | 10627 | 61.61 | 4.197e-15 | 1.495 |
| chr1:25589335 | rs28670433 | RSRP1 | A>G | 511 | 14122 | 57.22 | 3.889e-14 | 1.409 |
| chr3:66548271 | rs3915033 | LRIG1 | A>C | 897 | 27013 | 56.85 | 4.707e-14 | 1.297 |
| chr10:117649124 | rs7904803 | ATRNL1 | C>A | 629 | 18057 | 56.42 | 5.857e-14 | 1.36 |
| chr23:64367019 | rs7064929 | - | G>A | 585 | 16981 | 55.38 | 9.943e-14 | 1.372 |
| chr23:19215613 | rs5955734 | - | C>G | 934 | 29091 | 54.1 | 1.909e-13 | 1.284 |
| chr8:47318121 | rs13276653 | - | C>T | 577 | 16450 | 53.24 | 2.957e-13 | 1.365 |
| chr3:188327555 | rs7645635 | LPP | T>C | 496 | 13880 | 51.2 | 8.338e-13 | 1.389 |
| chr23:50659210 | Affx-52372905 | BMP15 | C>CTCT | 385 | 10553 | 51.04 | 9.061e-13 | 1.451 |
| chr1:25555672 | rs10903036 | SYF2 | C>T | 473 | 13140 | 51.02 | 9.161e-13 | 1.399 |
| chr17:58508582 | rs8071181 | C17orf64 | G>A | 526 | 14891 | 50.72 | 1.063e-12 | 1.374 |
| chr12:56755058 | rs4301822 | APOF | A>G | 442 | 12170 | 50.67 | 1.094e-12 | 1.414 |
| chr8:145639681 | rs1871534 | SLC39A4 | G>C | 606 | 17539 | 50.52 | 1.179e-12 | 1.345 |
| chr13:98302186 | rs6491359 | - | A>C | 916 | 28142 | 48.27 | 3.716e-12 | 1.268 |
| chr7:107689844 | rs10260756 | LAMB4 | G>T | 687 | 20409 | 47.66 | 5.066e-12 | 1.311 |
| chr1:159174683 | rs2814778 | ACKR1 | T>C | 637 | 18740 | 47.47 | 5.596e-12 | 1.324 |
| chr7:137347299 | rs7797609 | DGKI | T>C | 676 | 20062 | 47.25 | 6.234e-12 | 1.312 |
| chr19:7861485 | rs6603125 | - | A>C | 604 | 17661 | 47.23 | 6.311e-12 | 1.332 |
| chr23:110722596 | rs73549358 | - | C>T | 478 | 13777 | 47.19 | 6.438e-12 | 1.38 |
| chr9:15266052 | rs11788465 | TTC39B | G>T | 882 | 40627 | 25.32 | 4.868e-07 | 0.8399 |
| chr8:133836206 | rs10102374 | PHF20L1 | A>C | 1130 | 38173 | 23.32 | 1.368e-06 | 1.161 |
| chr8:98000151 | rs2853272 | CPQ | C>G | 645 | 20818 | 22.63 | 1.96e-06 | 1.212 |
| chr4:177542973 | rs13111989 | - | A>G | 6227 | 255185 | 21.13 | 4.296e-06 | 0.9333 |
| chr19:55569915 | rs2365720 | RDH13 | A>C | 7811 | 291617 | 21.1 | 4.365e-06 | 1.067 |
| chr13:108454238 | rs79290202 | FAM155A | C>T | 618 | 20046 | 20.73 | 5.293e-06 | 1.207 |
| chr6:21539166 | rs9358438 | - | T>C | 4847 | 178169 | 20.39 | 6.3e-06 | 1.077 |
| chr2:226940969 | rs16866816 | - | C>T | 1257 | 55469 | 20.2 | 6.96e-06 | 0.8765 |
| chr20:48991112 | rs13043301 | - | C>T | 1197 | 52954 | 20.13 | 7.227e-06 | 0.8741 |
| chr11:16856941 | rs34711318 | PLEKHA7 | C>T | 4466 | 163675 | 20.07 | 7.47e-06 | 1.079 |
| chr9:78898645 | rs10124180 | PCSK5 | A>C | 1495 | 65156 | 19.83 | 8.486e-06 | 0.8866 |
| chr7:22607062 | rs59026448 | STEAP1B | A>G | 526 | 24858 | 19.75 | 8.812e-06 | 0.8205 |
| chr12:123532142 | rs80326885 | PITPNM2 | T>C | 531 | 25063 | 19.68 | 9.158e-06 | 0.8216 |
| chr10:134553785 | rs2148666 | INPP5A | T>C | 8517 | 344661 | 19.56 | 9.75e-06 | 0.9407 |
| chr7:6974872 | rs117557765 | - | G>C | 789 | 26298 | 19.39 | 1.066e-05 | 1.176 |
| chr16:30546488 | rs6565191 | ZNF747 | G>A | 9505 | 357706 | 18.84 | 1.42e-05 | 1.061 |
| chr16:78532175 | rs117856896 | WWOX | C>T | 651 | 29989 | 18.56 | 1.642e-05 | 0.8412 |
| chr2:50228459 | rs6706613 | NRXN1 | C>T | 3979 | 145528 | 18.29 | 1.899e-05 | 1.078 |
| chr7:22603615 | rs17366199 | STEAP1B | G>A | 366 | 17818 | 18.25 | 1.936e-05 | 0.797 |
| chr13:53628524 | rs2226195 | - | A>G | 7726 | 289341 | 18.19 | 1.998e-05 | 1.062 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr8:133836206 | rs10102374 | PHF20L1 | A>C | 1130 | 4294 | 24.22 | 8.616e-07 | 1.183 |
| chr9:15266052 | rs11788465 | TTC39B | G>T | 882 | 4667 | 22.43 | 2.184e-06 | 0.8376 |
| chr6:21539166 | rs9358438 | - | T>C | 4847 | 20266 | 21.17 | 4.193e-06 | 1.086 |
| chr16:73831352 | rs72803158 | ZFHX3 | G>A | 781 | 2907 | 20.94 | 4.734e-06 | 1.206 |
| chr6:21522433 | rs9356780 | - | A>C | 3659 | 15121 | 20.41 | 6.25e-06 | 1.095 |
| chr13:108454238 | rs79290202 | FAM155A | C>T | 618 | 2257 | 20.11 | 7.314e-06 | 1.229 |
| chr8:39589418 | rs13252469 | - | T>C | 3825 | 15885 | 19.82 | 8.502e-06 | 1.092 |
| chr12:19227770 | rs76980484 | - | C>T | 799 | 2997 | 19.82 | 8.528e-06 | 1.197 |
| chr16:88615884 | rs8060566 | - | G>A | 3227 | 13296 | 19.6 | 9.544e-06 | 1.098 |
| chr5:9859450 | rs60283704 | - | C>T | 2747 | 13366 | 19.42 | 1.048e-05 | 0.9062 |
| chr2:182092599 | rs77700148 | - | T>C | 416 | 1458 | 19.36 | 1.083e-05 | 1.279 |
| chr20:48991112 | rs13043301 | - | C>T | 1197 | 6108 | 19.13 | 1.219e-05 | 0.8676 |
| chr17:77754569 | rs7217395 | CBX2 | C>T | 7560 | 35295 | 18.73 | 1.509e-05 | 0.935 |
| chr23:9242569 | rs41304711 | FAM9B | T>C | 249 | 842 | 18.57 | 1.634e-05 | 1.366 |
| chr4:65511600 | rs114716175 | - | C>G | 582 | 2136 | 18.0 | 2.214e-05 | 1.222 |
| chr13:53628524 | rs2226195 | - | A>G | 7726 | 33050 | 17.92 | 2.3e-05 | 1.068 |
| chr22:27562140 | rs9306436 | - | A>G | 9806 | 42210 | 17.85 | 2.396e-05 | 1.064 |
| chr8:19392430 | rs10503651 | CSGALNACT1 | C>T | 1691 | 6764 | 17.61 | 2.709e-05 | 1.126 |
| chr16:74069595 | rs67406934 | - | G>A | 1147 | 4473 | 17.61 | 2.712e-05 | 1.153 |
| chr3:179637106 | rs34625764 | PEX5L | C>T | 2906 | 14039 | 17.52 | 2.836e-05 | 0.9127 |
Associated Diseases ⓘ
| ID | Name | Top Correlation |
|---|---|---|
| ICD: I517 | Cardiomegaly | 7/20 |
| ICD: O049 | Complete or unspecified, without complication | 6/20 |