Statistics
| Case | Control |
|---|---|
| 8273 | 451921 |
Phenotype Definition
A circumscribed, solid elevation of skin with no visible fluid, varying in size from a pinhead to less than 10mm in diameter at the widest point. [HPO:skoehler]
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr6:396321 | rs12203592 | IRF4 | C>T | 4156 | 197049 | 115.0 | 8.001e-27 | 1.213 |
| chr6:421281 | rs62389423 | - | G>A | 3341 | 160695 | 73.58 | 9.654e-18 | 1.181 |
| chr16:89986117 | Affx-35293625 | MC1R | C>T | 1982 | 93096 | 55.99 | 7.269e-14 | 1.197 |
| chr16:89818732 | rs12931267 | FANCA | C>G | 1947 | 92106 | 49.89 | 1.625e-12 | 1.187 |
| chr16:90067136 | rs78800020 | - | G>C | 1928 | 91596 | 46.17 | 1.082e-11 | 1.18 |
| chr16:90067184 | rs73283869 | - | G>A | 1841 | 87926 | 41.58 | 1.131e-10 | 1.174 |
| chr16:89434541 | rs111460975 | ANKRD11 | A>G | 2760 | 136085 | 40.35 | 2.121e-10 | 1.142 |
| chr16:90048395 | rs45610233 | - | C>T | 1737 | 82757 | 40.15 | 2.35e-10 | 1.176 |
| chr6:502106 | rs75891606 | EXOC2 | A>G | 1018 | 46188 | 39.88 | 2.707e-10 | 1.229 |
| chr16:89507330 | rs74836424 | ANKRD11 | C>T | 1574 | 74945 | 36.48 | 1.542e-09 | 1.175 |
| chr16:90093075 | rs77270200 | GAS8 | G>A | 1952 | 94526 | 36.44 | 1.572e-09 | 1.158 |
| chr16:89383725 | rs3114908 | ANKRD11 | C>T | 6618 | 344697 | 33.73 | 6.324e-09 | 1.096 |
| chr25:2625922 | rs5982839 | - | G>A | 448 | 32377 | 33.55 | 6.93e-09 | 0.7571 |
| chr16:89687407 | rs2280374 | DPEP1 | C>T | 1932 | 94428 | 31.01 | 2.564e-08 | 1.145 |
| chr6:170242949 | rs9396958 | - | T>C | 197 | 15917 | 29.2 | 6.537e-08 | 0.679 |
| chr20:32588095 | rs2284378 | RALY | C>T | 6191 | 322854 | 28.91 | 7.58e-08 | 1.09 |
| chr16:90024202 | rs8049897 | DEF8 | G>A | 3208 | 162155 | 28.39 | 9.908e-08 | 1.111 |
| chr16:13005559 | Affx-12392256 | SHISA9 | A>G | 2039 | 125382 | 27.69 | 1.426e-07 | 0.8825 |
| chr20:32536364 | rs973409 | - | C>T | 6271 | 327147 | 27.64 | 1.459e-07 | 1.087 |
| chr10:92439545 | rs17452486 | - | C>T | 778 | 35687 | 27.04 | 1.99e-07 | 1.212 |
| chr6:396321 | rs12203592 | IRF4 | C>T | 4127 | 194788 | 109.1 | 1.58e-25 | 1.209 |
| chr6:421281 | rs62389423 | - | G>A | 3315 | 158550 | 69.48 | 7.738e-17 | 1.177 |
| chr16:89986117 | Affx-35293625 | MC1R | C>T | 1970 | 92221 | 51.81 | 6.103e-13 | 1.191 |
| chr16:89818732 | rs12931267 | FANCA | C>G | 1935 | 91160 | 46.39 | 9.698e-12 | 1.181 |
| chr16:90067136 | rs78800020 | - | G>C | 1827 | 86366 | 41.12 | 1.43e-10 | 1.174 |
| chr16:90067184 | rs73283869 | - | G>A | 1811 | 85915 | 39.51 | 3.266e-10 | 1.171 |
| chr16:90048395 | rs45610233 | - | C>T | 1726 | 81930 | 37.01 | 1.176e-09 | 1.169 |
| chr16:89687407 | rs2280374 | DPEP1 | C>T | 1884 | 90096 | 36.73 | 1.358e-09 | 1.162 |
| chr16:89434541 | rs111460975 | ANKRD11 | A>G | 2737 | 134411 | 36.41 | 1.599e-09 | 1.136 |
| chr6:502106 | rs75891606 | EXOC2 | A>G | 1008 | 45687 | 36.15 | 1.826e-09 | 1.218 |
| chr16:89507330 | rs74836424 | ANKRD11 | C>T | 1566 | 74212 | 34.13 | 5.163e-09 | 1.17 |
| chr16:90093075 | rs77270200 | GAS8 | G>A | 1922 | 92528 | 34.07 | 5.329e-09 | 1.154 |
| chr16:89683240 | rs1968499 | DPEP1 | A>G | 2279 | 112247 | 29.41 | 5.862e-08 | 1.132 |
| chr16:90024202 | rs8049897 | DEF8 | G>A | 3087 | 154192 | 28.94 | 7.456e-08 | 1.114 |
| chr16:89383725 | rs3114908 | ANKRD11 | C>T | 6332 | 328015 | 28.04 | 1.19e-07 | 1.089 |
| chr16:89755903 | rs258322 | CDK10 | G>A | 2134 | 105435 | 23.8 | 1.07e-06 | 1.121 |
| chr20:32588095 | rs2284378 | RALY | C>T | 6033 | 313226 | 23.38 | 1.327e-06 | 1.082 |
| chr10:92439545 | rs17452486 | - | C>T | 761 | 35081 | 22.56 | 2.033e-06 | 1.195 |
| chr20:32536364 | rs973409 | - | C>T | 6125 | 318127 | 22.54 | 2.061e-06 | 1.08 |
| chr20:32644396 | rs2284386 | RALY | A>G | 6047 | 314430 | 22.14 | 2.534e-06 | 1.08 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr6:396321 | rs12203592 | IRF4 | C>T | 4127 | 43323 | 65.97 | 4.57e-16 | 1.165 |
| chr6:421281 | rs62389423 | - | G>A | 3315 | 35195 | 41.77 | 1.026e-10 | 1.14 |
| chr6:502106 | rs75891606 | EXOC2 | A>G | 1008 | 10069 | 26.98 | 2.059e-07 | 1.193 |
| chr16:89986117 | Affx-35293625 | MC1R | C>T | 1970 | 20793 | 25.83 | 3.728e-07 | 1.136 |
| chr16:89434541 | rs111460975 | ANKRD11 | A>G | 2737 | 29488 | 25.44 | 4.564e-07 | 1.117 |
| chr16:89818732 | rs12931267 | FANCA | C>G | 1935 | 20557 | 22.23 | 2.42e-06 | 1.127 |
| chr25:2625922 | rs5982839 | - | G>A | 311 | 4811 | 21.93 | 2.83e-06 | 0.759 |
| chr16:89383725 | rs3114908 | ANKRD11 | C>T | 6332 | 71319 | 21.05 | 4.468e-06 | 1.08 |
| chr17:57511073 | rs4968363 | - | T>C | 2130 | 22878 | 19.96 | 7.9e-06 | 1.114 |
| chr8:69379087 | rs55654401 | C8orf34 | G>T | 7575 | 92917 | 19.71 | 9e-06 | 0.9304 |
| chr3:153523526 | rs78235351 | - | A>G | 394 | 3687 | 19.68 | 9.171e-06 | 1.268 |
| chr6:105152142 | rs80223955 | - | A>G | 499 | 4800 | 19.58 | 9.637e-06 | 1.235 |
| chr10:92439545 | rs17452486 | - | C>T | 761 | 7629 | 19.57 | 9.704e-06 | 1.188 |
| chr16:90067136 | rs78800020 | - | G>C | 1827 | 19475 | 19.27 | 1.133e-05 | 1.121 |
| chr8:144803450 | rs34410761 | MAPK15 | C>T | 395 | 3708 | 18.8 | 1.449e-05 | 1.261 |
| chr7:131320871 | rs10257102 | - | A>G | 1303 | 17321 | 18.72 | 1.512e-05 | 0.878 |
| chr7:17106017 | rs7805128 | AHR | T>G | 7106 | 87229 | 18.5 | 1.698e-05 | 0.932 |
| chr8:2037281 | rs1025797 | MYOM2 | C>A | 2331 | 29948 | 18.43 | 1.766e-05 | 0.9052 |
| chr15:97535478 | rs73472870 | - | G>A | 463 | 6694 | 18.39 | 1.804e-05 | 0.8117 |
| chr8:144798592 | rs62524242 | MAPK15 | C>T | 399 | 3778 | 18.09 | 2.103e-05 | 1.254 |
Associated Diseases ⓘ
| ID | Name | Top Correlation |
|---|---|---|
| ICD: L570 | Actinic keratosis | 7/20 |