Statistics
| Case | Control |
|---|---|
| 506 | 459688 |
Phenotype Definition
Inflammation or infection of the external auditory canal (EAC), the auricle, or both. [http://search.medscape.com/search/?q=otitis%20externa, ORCID:0000-0001-5208-3432]
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr7:12671533 | rs17357392 | SCIN | A>G | 364 | 264061 | 22.06 | 2.645e-06 | 1.351 |
| chr6:55952657 | rs114655670 | COL21A1 | A>G | 32 | 12859 | 21.89 | 2.888e-06 | 2.265 |
| chr9:86702203 | rs114662423 | - | G>T | 110 | 64661 | 21.64 | 3.295e-06 | 1.591 |
| chr14:89535735 | rs117831883 | - | C>T | 36 | 15251 | 21.61 | 3.343e-06 | 2.159 |
| chr8:91488124 | rs12114208 | - | A>G | 33 | 13601 | 21.38 | 3.759e-06 | 2.219 |
| chr6:10596347 | rs79403763 | GCNT2 | C>A | 214 | 144086 | 20.34 | 6.467e-06 | 1.409 |
| chr16:56717596 | rs8051405 | MT1X | G>A | 381 | 412133 | 20.31 | 6.572e-06 | 0.7499 |
| chr13:89649708 | rs9522412 | - | G>A | 84 | 46931 | 20.28 | 6.701e-06 | 1.66 |
| chr2:105819694 | rs79058579 | - | G>A | 38 | 16770 | 20.24 | 6.822e-06 | 2.07 |
| chr2:149208646 | rs11690040 | MBD5 | G>A | 422 | 316869 | 20.03 | 7.634e-06 | 1.321 |
| chr3:43910012 | rs78113114 | - | C>T | 29 | 11547 | 19.94 | 7.975e-06 | 2.267 |
| chr1:37070552 | rs72918759 | - | G>A | 54 | 27024 | 19.28 | 1.131e-05 | 1.83 |
| chr13:101727167 | rs34045536 | NALCN | T>G | 37 | 16467 | 19.11 | 1.234e-05 | 2.047 |
| chr5:155780558 | rs17053462 | SGCD | A>G | 145 | 92062 | 19.02 | 1.295e-05 | 1.472 |
| chr1:12681568 | rs12117229 | - | G>A | 606 | 482085 | 18.88 | 1.389e-05 | 1.305 |
| chr1:9254456 | rs79942320 | - | G>A | 26 | 10239 | 18.85 | 1.418e-05 | 2.312 |
| chr8:28534122 | rs409235 | EXTL3 | T>C | 40 | 18386 | 18.77 | 1.478e-05 | 1.984 |
| chr16:30887482 | rs117957142 | BCL7C | T>C | 11 | 33006 | 18.72 | 1.517e-05 | 0.2917 |
| chr12:624825 | rs16931464 | B4GALNT3 | G>A | 61 | 32006 | 18.54 | 1.663e-05 | 1.752 |
| chr6:26462356 | rs12660069 | BTN2A1 | C>T | 60 | 31464 | 18.29 | 1.897e-05 | 1.753 |
| chr9:86702203 | rs114662423 | - | G>T | 102 | 59572 | 22.07 | 2.626e-06 | 1.627 |
| chr1:37070552 | rs72918759 | - | G>A | 52 | 25271 | 21.46 | 3.608e-06 | 1.913 |
| chr16:19369547 | rs17224504 | - | T>G | 126 | 77684 | 21.46 | 3.611e-06 | 1.551 |
| chr3:43910012 | rs78113114 | - | C>T | 29 | 11403 | 21.35 | 3.829e-06 | 2.331 |
| chr6:133785281 | rs73544945 | EYA4 | G>A | 106 | 62857 | 21.25 | 4.03e-06 | 1.599 |
| chr16:56717596 | rs8051405 | MT1X | G>A | 353 | 391190 | 20.9 | 4.844e-06 | 0.7386 |
| chr14:70724632 | rs35814863 | - | C>T | 390 | 292747 | 20.82 | 5.033e-06 | 1.342 |
| chr5:155780558 | rs17053462 | SGCD | A>G | 130 | 80683 | 20.7 | 5.369e-06 | 1.529 |
| chr13:101727167 | rs34045536 | NALCN | T>G | 37 | 16288 | 20.53 | 5.876e-06 | 2.101 |
| chr12:628090 | rs2286781 | B4GALNT3 | G>A | 88 | 50232 | 20.42 | 6.223e-06 | 1.648 |
| chr2:149208646 | rs11690040 | MBD5 | G>A | 407 | 308688 | 20.41 | 6.242e-06 | 1.335 |
| chr13:89649708 | rs9522412 | - | G>A | 82 | 46142 | 20.38 | 6.346e-06 | 1.673 |
| chr12:624825 | rs16931464 | B4GALNT3 | G>A | 50 | 24510 | 20.18 | 7.03e-06 | 1.899 |
| chr14:70759011 | rs72733748 | - | T>G | 285 | 320229 | 20.1 | 7.345e-06 | 0.7317 |
| chr5:131430118 | rs657075 | - | G>A | 137 | 86794 | 19.99 | 7.801e-06 | 1.504 |
| chr8:91488124 | rs12114208 | - | A>G | 27 | 10859 | 19.31 | 1.113e-05 | 2.302 |
| chr7:103580446 | rs17157475 | RELN | T>C | 179 | 120838 | 18.98 | 1.322e-05 | 1.43 |
| chr6:55952657 | rs114655670 | COL21A1 | A>G | 30 | 12597 | 18.95 | 1.341e-05 | 2.198 |
| chr14:87262754 | rs117766384 | - | A>G | 32 | 13775 | 18.9 | 1.378e-05 | 2.145 |
| chr5:143254918 | rs113604162 | - | C>T | 31 | 13209 | 18.82 | 1.436e-05 | 2.166 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr18:42282685 | rs117297259 | SETBP1 | G>T | 30 | 18 | 31.39 | 2.112e-08 | 4.637 |
| chr9:86702203 | rs114662423 | - | G>T | 110 | 174 | 22.69 | 1.9e-06 | 1.822 |
| chr7:12671533 | rs17357392 | SCIN | A>G | 364 | 768 | 22.5 | 2.097e-06 | 1.438 |
| chr16:30887482 | rs117957142 | BCL7C | T>C | 11 | 116 | 21.94 | 2.814e-06 | 0.2517 |
| chr2:149208646 | rs11690040 | MBD5 | G>A | 422 | 925 | 21.19 | 4.156e-06 | 1.404 |
| chr15:79327686 | rs736554 | RASGRF1 | T>C | 253 | 507 | 20.4 | 6.278e-06 | 1.478 |
| chr12:624825 | rs16931464 | B4GALNT3 | G>A | 61 | 81 | 19.62 | 9.462e-06 | 2.121 |
| chr14:66433199 | rs72718427 | - | C>T | 73 | 104 | 19.6 | 9.538e-06 | 1.981 |
| chr7:9659078 | rs34036504 | - | C>A | 126 | 215 | 19.42 | 1.048e-05 | 1.677 |
| chr5:43016132 | rs79178829 | - | T>C | 36 | 36 | 19.38 | 1.073e-05 | 2.745 |
| chr2:1929531 | rs115763552 | MYT1L | T>C | 33 | 32 | 19.29 | 1.124e-05 | 2.869 |
| chr1:20623275 | rs72647030 | VWA5B1 | C>A | 27 | 23 | 19.05 | 1.276e-05 | 3.258 |
| chr3:43910012 | rs78113114 | - | C>T | 29 | 26 | 18.69 | 1.537e-05 | 3.068 |
| chr10:92797757 | rs1431856 | - | C>T | 33 | 33 | 18.34 | 1.85e-05 | 2.781 |
| chr7:149875840 | rs6942481 | - | G>A | 106 | 175 | 18.26 | 1.931e-05 | 1.723 |
| chr6:169225162 | rs6940011 | - | A>G | 70 | 101 | 18.24 | 1.947e-05 | 1.957 |
| chr16:56717596 | rs8051405 | MT1X | G>A | 381 | 1275 | 18.16 | 2.027e-05 | 0.7296 |
| chr18:6717524 | rs77660625 | - | G>A | 48 | 59 | 17.98 | 2.234e-05 | 2.264 |
| chr8:94370855 | rs1367793 | - | T>C | 342 | 737 | 17.58 | 2.76e-05 | 1.385 |
| chr18:23801098 | rs36019834 | - | T>C | 457 | 1473 | 17.36 | 3.098e-05 | 0.7419 |
| chr18:42282685 | rs117297259 | SETBP1 | G>T | 29 | 17 | 30.97 | 2.619e-08 | 4.746 |
| chr9:86702203 | rs114662423 | - | G>T | 102 | 148 | 27.46 | 1.601e-07 | 2.0 |
| chr14:66433199 | rs72718427 | - | C>T | 72 | 99 | 21.34 | 3.85e-06 | 2.06 |
| chr16:30887482 | rs117957142 | BCL7C | T>C | 11 | 113 | 20.91 | 4.812e-06 | 0.2585 |
| chr2:149208646 | rs11690040 | MBD5 | G>A | 407 | 893 | 20.89 | 4.856e-06 | 1.414 |
| chr5:43016132 | rs79178829 | - | T>C | 35 | 33 | 20.86 | 4.94e-06 | 2.925 |
| chr2:1929531 | rs115763552 | MYT1L | T>C | 33 | 31 | 20.31 | 6.586e-06 | 2.969 |
| chr18:6717524 | rs77660625 | - | G>A | 47 | 54 | 20.3 | 6.617e-06 | 2.429 |
| chr1:20623275 | rs72647030 | VWA5B1 | C>A | 27 | 22 | 20.24 | 6.825e-06 | 3.414 |
| chr14:70759011 | rs72733748 | - | T>G | 285 | 991 | 20.02 | 7.68e-06 | 0.6985 |
| chr16:56717596 | rs8051405 | MT1X | G>A | 353 | 1200 | 19.63 | 9.4e-06 | 0.7118 |
| chr15:79327686 | rs736554 | RASGRF1 | T>C | 230 | 457 | 19.49 | 1.011e-05 | 1.491 |
| chr12:624825 | rs16931464 | B4GALNT3 | G>A | 50 | 61 | 19.47 | 1.023e-05 | 2.306 |
| chr3:43910012 | rs78113114 | - | C>T | 29 | 26 | 18.73 | 1.508e-05 | 3.074 |
| chr7:12671533 | rs17357392 | SCIN | A>G | 341 | 733 | 18.41 | 1.777e-05 | 1.404 |
| chr5:172726334 | rs4242166 | - | G>A | 215 | 425 | 18.26 | 1.929e-05 | 1.487 |
| chr16:56717509 | rs6499851 | MT1X | C>T | 420 | 941 | 18.11 | 2.087e-05 | 1.378 |
| chr4:33062599 | rs12502719 | - | A>G | 25 | 21 | 17.99 | 2.223e-05 | 3.306 |
| chr2:1957544 | rs115255471 | MYT1L | T>G | 42 | 49 | 17.88 | 2.349e-05 | 2.404 |
| chr3:126787159 | rs11921451 | - | G>T | 326 | 697 | 17.73 | 2.547e-05 | 1.401 |
Associated Diseases ⓘ
| ID | Name | Top Correlation |
|---|---|---|
| ICD: H609 | Otitis externa, unspecified | 4/20 |
| ID | Name | Top Correlation |
|---|