Statistics
| Case | Control |
|---|---|
| 3151 | 457043 |
Phenotype Definition
Inflammation of the urethra. [PMID:26220178]
Phenotype Comment
Urethritis is characterized by discharge, dysuria and/or urethral discomfort but may be asymptomatic. Common etiologies include gonococcal urethritis as well as infection by chlamydia trachomatis, mycoplasma genitalium, ureaplasma urealyticum, trichomonas vaginalis, anaerobes, herpes simplex virus, and adenovirus.
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr5:96496663 | rs78365495 | RIOK2 | A>G | 157 | 14458 | 33.27 | 8.014e-09 | 1.591 |
| chr4:45532030 | rs28456680 | - | T>C | 360 | 40718 | 22.87 | 1.729e-06 | 1.296 |
| chr10:28167091 | rs79444079 | ARMC4 | G>T | 196 | 20397 | 22.13 | 2.549e-06 | 1.406 |
| chr9:29638167 | rs546929 | - | G>T | 760 | 93866 | 21.92 | 2.84e-06 | 1.198 |
| chr3:3256506 | rs73011180 | - | C>T | 404 | 46793 | 21.27 | 3.984e-06 | 1.268 |
| chr18:5313164 | rs8087030 | - | T>G | 909 | 114433 | 20.67 | 5.451e-06 | 1.177 |
| chr7:103490604 | rs74502433 | RELN | A>G | 368 | 42374 | 20.55 | 5.817e-06 | 1.276 |
| chr15:37450479 | rs72710684 | - | G>A | 181 | 18914 | 20.02 | 7.683e-06 | 1.401 |
| chr4:43196539 | rs11944497 | - | C>T | 1895 | 251647 | 19.81 | 8.551e-06 | 1.129 |
| chr1:216886001 | rs2789718 | ESRRG | G>A | 1050 | 134166 | 19.68 | 9.16e-06 | 1.161 |
| chr4:161208587 | rs167178 | - | C>G | 1120 | 143645 | 19.65 | 9.297e-06 | 1.158 |
| chr9:3334185 | rs10971452 | RFX3 | G>A | 935 | 154925 | 19.49 | 1.011e-05 | 0.8555 |
| chr1:81159163 | rs841668 | - | T>C | 1631 | 215331 | 19.41 | 1.054e-05 | 1.134 |
| chr15:87664115 | rs8033765 | - | T>C | 2209 | 345545 | 19.33 | 1.103e-05 | 0.8917 |
| chr15:78081050 | rs11629830 | LINGO1 | G>T | 1223 | 198860 | 19.14 | 1.213e-05 | 0.8704 |
| chr3:144003533 | rs77264078 | - | G>C | 174 | 18190 | 18.99 | 1.312e-05 | 1.398 |
| chr12:6006026 | rs80222654 | ANO2 | G>A | 108 | 10328 | 18.83 | 1.433e-05 | 1.522 |
| chr14:21168084 | rs11541061 | RNASE4 | C>T | 1441 | 230466 | 18.81 | 1.444e-05 | 0.878 |
| chr4:138257423 | rs12647160 | - | A>G | 2228 | 299407 | 18.69 | 1.536e-05 | 1.119 |
| chr1:72901383 | rs114086144 | - | G>A | 394 | 46214 | 18.67 | 1.557e-05 | 1.252 |
| chr5:96496663 | rs78365495 | RIOK2 | A>G | 149 | 13840 | 30.31 | 3.691e-08 | 1.576 |
| chr9:29638167 | rs546929 | - | G>T | 683 | 82724 | 24.47 | 7.531e-07 | 1.223 |
| chr4:45532030 | rs28456680 | - | T>C | 336 | 37523 | 23.53 | 1.232e-06 | 1.313 |
| chr4:43196539 | rs11944497 | - | C>T | 1763 | 231253 | 23.21 | 1.449e-06 | 1.145 |
| chr18:5313164 | rs8087030 | - | T>G | 852 | 105830 | 22.96 | 1.651e-06 | 1.194 |
| chr4:161208587 | rs167178 | - | C>G | 1033 | 130303 | 22.79 | 1.807e-06 | 1.178 |
| chr3:3256506 | rs73011180 | - | C>T | 400 | 46150 | 21.67 | 3.231e-06 | 1.273 |
| chr1:72901383 | rs114086144 | - | G>A | 380 | 43791 | 21.02 | 4.538e-06 | 1.275 |
| chr7:103490604 | rs74502433 | RELN | A>G | 362 | 41491 | 20.97 | 4.673e-06 | 1.282 |
| chr15:37450479 | rs72710684 | - | G>A | 179 | 18563 | 20.68 | 5.423e-06 | 1.412 |
| chr3:144003533 | rs77264078 | - | G>C | 171 | 17681 | 19.92 | 8.056e-06 | 1.413 |
| chr16:26812516 | rs916776 | - | G>T | 2531 | 342506 | 19.77 | 8.751e-06 | 1.122 |
| chr4:138257423 | rs12647160 | - | A>G | 2136 | 286062 | 19.4 | 1.058e-05 | 1.125 |
| chr2:180897167 | rs2584199 | - | C>T | 509 | 61119 | 19.31 | 1.111e-05 | 1.226 |
| chr9:3334185 | rs10971452 | RFX3 | G>A | 880 | 146108 | 19.08 | 1.252e-05 | 0.8529 |
| chr25:2609983 | rs2236738 | - | C>T | 2347 | 316563 | 19.06 | 1.269e-05 | 1.121 |
| chr6:130485558 | rs1932105 | SAMD3 | T>C | 1526 | 200680 | 18.9 | 1.378e-05 | 1.137 |
| chr3:31250362 | rs62236277 | - | A>G | 1661 | 219166 | 18.87 | 1.396e-05 | 1.133 |
| chr1:35057900 | rs61776001 | - | G>A | 1611 | 212316 | 18.75 | 1.487e-05 | 1.134 |
| chr15:78081050 | rs11629830 | LINGO1 | G>T | 1171 | 190354 | 18.6 | 1.61e-05 | 0.8693 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr5:96496663 | rs78365495 | RIOK2 | A>G | 157 | 6615 | 34.8 | 3.647e-09 | 1.612 |
| chr10:28167091 | rs79444079 | ARMC4 | G>T | 196 | 9342 | 23.53 | 1.232e-06 | 1.424 |
| chr4:45532030 | rs28456680 | - | T>C | 360 | 18853 | 22.88 | 1.725e-06 | 1.298 |
| chr9:29638167 | rs546929 | - | G>T | 760 | 43499 | 21.82 | 2.996e-06 | 1.199 |
| chr7:103490604 | rs74502433 | RELN | A>G | 368 | 19540 | 21.26 | 4.002e-06 | 1.283 |
| chr4:161208587 | rs167178 | - | C>G | 1120 | 66306 | 21.01 | 4.558e-06 | 1.164 |
| chr1:216886001 | rs2789718 | ESRRG | G>A | 1050 | 61889 | 20.96 | 4.682e-06 | 1.168 |
| chr4:43196539 | rs11944497 | - | C>T | 1895 | 116386 | 20.62 | 5.59e-06 | 1.132 |
| chr10:28224075 | rs35242712 | ARMC4 | G>A | 195 | 9494 | 20.6 | 5.658e-06 | 1.393 |
| chr15:37450479 | rs72710684 | - | G>A | 181 | 8717 | 20.51 | 5.944e-06 | 1.409 |
| chr9:3334185 | rs10971452 | RFX3 | G>A | 935 | 72008 | 20.18 | 7.056e-06 | 0.8527 |
| chr18:5313164 | rs8087030 | - | T>G | 909 | 53127 | 20.05 | 7.558e-06 | 1.175 |
| chr4:148229540 | rs2714887 | - | A>G | 202 | 9950 | 19.8 | 8.576e-06 | 1.377 |
| chr14:21168084 | rs11541061 | RNASE4 | C>T | 1441 | 107208 | 19.53 | 9.9e-06 | 0.8754 |
| chr12:6006026 | rs80222654 | ANO2 | G>A | 108 | 4748 | 19.37 | 1.074e-05 | 1.535 |
| chr4:138257423 | rs12647160 | - | A>G | 2228 | 138560 | 19.33 | 1.098e-05 | 1.122 |
| chr3:144003533 | rs77264078 | - | G>C | 174 | 8397 | 19.26 | 1.138e-05 | 1.404 |
| chr2:158117300 | rs16841426 | GALNT5 | C>T | 965 | 56772 | 19.19 | 1.185e-05 | 1.166 |
| chr15:78081050 | rs11629830 | LINGO1 | G>T | 1223 | 92241 | 19.16 | 1.199e-05 | 0.8699 |
| chr1:81159163 | rs841668 | - | T>C | 1631 | 99930 | 18.85 | 1.412e-05 | 1.133 |
| chr5:96496663 | rs78365495 | RIOK2 | A>G | 149 | 6325 | 32.09 | 1.469e-08 | 1.601 |
| chr4:161208587 | rs167178 | - | C>G | 1033 | 60319 | 23.66 | 1.148e-06 | 1.183 |
| chr4:45532030 | rs28456680 | - | T>C | 336 | 17399 | 23.51 | 1.244e-06 | 1.315 |
| chr9:29638167 | rs546929 | - | G>T | 683 | 38510 | 23.5 | 1.247e-06 | 1.219 |
| chr4:43196539 | rs11944497 | - | C>T | 1763 | 107274 | 23.29 | 1.394e-06 | 1.146 |
| chr18:5313164 | rs8087030 | - | T>G | 852 | 49200 | 22.31 | 2.321e-06 | 1.192 |
| chr7:103490604 | rs74502433 | RELN | A>G | 362 | 19152 | 21.75 | 3.107e-06 | 1.289 |
| chr15:37450479 | rs72710684 | - | G>A | 179 | 8536 | 21.62 | 3.322e-06 | 1.425 |
| chr25:2609983 | rs2236738 | - | C>T | 2347 | 146344 | 21.06 | 4.447e-06 | 1.128 |
| chr1:72901383 | rs114086144 | - | G>A | 380 | 20302 | 21.04 | 4.506e-06 | 1.277 |
| chr3:144003533 | rs77264078 | - | G>C | 171 | 8155 | 20.46 | 6.103e-06 | 1.423 |
| chr4:138257423 | rs12647160 | - | A>G | 2136 | 132456 | 20.44 | 6.15e-06 | 1.129 |
| chr2:180897167 | rs2584199 | - | C>T | 509 | 28311 | 19.54 | 9.875e-06 | 1.229 |
| chr16:26812516 | rs916776 | - | G>T | 2531 | 159043 | 19.54 | 9.872e-06 | 1.121 |
| chr3:31250362 | rs62236277 | - | A>G | 1661 | 101542 | 19.5 | 1.006e-05 | 1.136 |
| chr9:3334185 | rs10971452 | RFX3 | G>A | 880 | 67863 | 19.15 | 1.211e-05 | 0.8522 |
| chr15:87664115 | rs8033765 | - | T>C | 2016 | 146828 | 18.88 | 1.394e-05 | 0.8886 |
| chr3:3256506 | rs73011180 | - | C>T | 400 | 21745 | 18.83 | 1.432e-05 | 1.253 |
| chr1:35057900 | rs61776001 | - | G>A | 1611 | 98516 | 18.79 | 1.461e-05 | 1.134 |
| chr12:6006026 | rs80222654 | ANO2 | G>A | 105 | 4635 | 18.56 | 1.649e-05 | 1.53 |
Associated Diseases ⓘ
| ID | Name | Top Correlation |
|---|---|---|
| ICD: N72 | Inflammatory disease of cervix uteri | 2/20 |
| ID | Name | Top Correlation |
|---|---|---|
| ICD-10: N303 | Trigonitis | 0/20 |
| ICD-10: N342 | Other urethritis | 0/20 |
| ICD-10: N419 | Inflammatory disease of prostate, unspecified | 0/20 |
| ICD-10: N762 | Acute vulvitis | 0/20 |