Statistics
| Case | Control |
|---|---|
| 613 | 459581 |
Phenotype Definition
Deposition of large, diffuse cotton wool amyloid plaques (CWPs) lacking a dense core and associated neuritic changes. [PMID:20460383]
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|---|---|---|---|---|---|---|---|
| chr23:151996723 | rs142811420 | CETN2 | T>C | 35 | 12189 | 25.95 | 3.508e-07 | 2.346 |
| chr6:502106 | rs75891606 | EXOC2 | A>G | 102 | 47104 | 23.25 | 1.426e-06 | 1.637 |
| chr6:100241479 | rs9495569 | - | A>G | 57 | 22646 | 22.59 | 2.002e-06 | 1.885 |
| chr4:127058428 | rs515514 | - | C>T | 453 | 274570 | 22.35 | 2.272e-06 | 1.314 |
| chr1:232550611 | rs12024992 | SIPA1L2 | T>C | 32 | 10593 | 21.76 | 3.091e-06 | 2.256 |
| chr7:86066506 | rs117929214 | - | A>G | 47 | 17771 | 21.73 | 3.135e-06 | 1.974 |
| chr8:144811278 | rs9969456 | FAM83H | G>A | 320 | 186124 | 21.61 | 3.344e-06 | 1.347 |
| chr8:69379087 | rs55654401 | C8orf34 | G>T | 543 | 459032 | 21.48 | 3.577e-06 | 0.7726 |
| chr8:144808747 | rs11136321 | FAM83H | A>G | 365 | 217915 | 21.39 | 3.751e-06 | 1.33 |
| chr7:151882672 | rs145848316 | KMT2C | C>A | 64 | 26434 | 21.22 | 4.09e-06 | 1.791 |
| chr8:55398033 | rs9792222 | - | C>T | 263 | 246448 | 21.06 | 4.45e-06 | 0.7298 |
| chr18:53787379 | rs11664983 | - | C>A | 151 | 76884 | 20.7 | 5.359e-06 | 1.479 |
| chr4:25686546 | rs17838935 | - | C>T | 34 | 11686 | 20.6 | 5.657e-06 | 2.161 |
| chr1:31223269 | rs116077605 | LAPTM5 | A>G | 81 | 36707 | 19.76 | 8.76e-06 | 1.657 |
| chr4:27125152 | rs10027736 | - | C>T | 37 | 13423 | 19.42 | 1.048e-05 | 2.055 |
| chr4:178681725 | rs72713676 | - | C>T | 39 | 14150 | 19.33 | 1.1e-05 | 2.017 |
| chr5:144975121 | rs17419257 | PRELID2 | G>A | 121 | 60523 | 19.18 | 1.188e-05 | 1.515 |
| chr3:34944013 | rs17032477 | - | A>G | 45 | 17078 | 19.1 | 1.241e-05 | 1.921 |
| chr11:78434112 | rs117214320 | TENM4 | C>A | 44 | 17017 | 18.93 | 1.358e-05 | 1.927 |
| chr5:99936178 | rs116695292 | - | A>G | 36 | 13003 | 18.84 | 1.421e-05 | 2.053 |
| chr6:502106 | rs75891606 | EXOC2 | A>G | 102 | 46593 | 26.88 | 2.167e-07 | 1.7 |
| chr7:86066506 | rs117929214 | - | A>G | 46 | 17209 | 23.54 | 1.224e-06 | 2.044 |
| chr7:151882672 | rs145848316 | KMT2C | C>A | 56 | 22488 | 22.12 | 2.56e-06 | 1.884 |
| chr5:144975121 | rs17419257 | PRELID2 | G>A | 118 | 58627 | 21.75 | 3.108e-06 | 1.566 |
| chr11:78434112 | rs117214320 | TENM4 | C>A | 44 | 16739 | 21.4 | 3.728e-06 | 2.008 |
| chr23:151996723 | rs142811420 | CETN2 | T>C | 31 | 11417 | 21.25 | 4.022e-06 | 2.273 |
| chr8:69379087 | rs55654401 | C8orf34 | G>T | 503 | 436532 | 21.2 | 4.143e-06 | 0.7659 |
| chr6:168070293 | rs112576008 | - | G>A | 47 | 18433 | 20.76 | 5.194e-06 | 1.947 |
| chr22:24610854 | rs117077425 | - | G>A | 44 | 16907 | 20.64 | 5.552e-06 | 1.984 |
| chr4:178681725 | rs72713676 | - | C>T | 38 | 13700 | 20.61 | 5.642e-06 | 2.082 |
| chr16:70837619 | rs77069808 | HYDIN | G>T | 85 | 40167 | 19.63 | 9.392e-06 | 1.638 |
| chr16:14382615 | rs76383741 | - | G>A | 29 | 9812 | 19.54 | 9.85e-06 | 2.247 |
| chr4:149283684 | rs72729952 | NR3C2 | G>C | 62 | 26969 | 19.26 | 1.141e-05 | 1.76 |
| chr4:127058428 | rs515514 | - | C>T | 406 | 252480 | 19.12 | 1.224e-05 | 1.303 |
| chr17:26122511 | rs28998810 | NOS2 | G>A | 55 | 23203 | 19.1 | 1.239e-05 | 1.813 |
| chr20:12193446 | rs116862624 | - | A>G | 111 | 55761 | 19.06 | 1.264e-05 | 1.54 |
| chr5:99936178 | rs116695292 | - | A>G | 35 | 12766 | 18.97 | 1.331e-05 | 2.079 |
| chr19:8929561 | rs118128745 | ZNF558 | T>C | 34 | 12361 | 18.82 | 1.438e-05 | 2.094 |
| chr15:22980776 | rs62008564 | CYFIP1 | C>T | 41 | 15929 | 18.62 | 1.591e-05 | 1.961 |
| chr4:25686546 | rs17838935 | - | C>T | 29 | 9996 | 18.43 | 1.76e-05 | 2.198 |
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds ratio |
|---|
Associated Diseases ⓘ
| ID | Name | Top Correlation |
|---|---|---|
| ICD: A498 | Other bacterial infections of unspecified site | 1/20 |
| ID | Name | Top Correlation |
|---|---|---|
| ICD-10: A499 | Bacterial infection, unspecified | 0/20 |