Klebsiella pneumoniae [K. pneumoniae] as the cause of diseases classified to other chapters
B96.1
Case/Control GWAS ⓘ
Statistics
| Case | Control |
|---|---|
| 564 | 459641 |
Top SNP Information
| Location | SNP | Gene | Ref>Alt | Alt in Case | Alt in Control | Chi-square | P-value | Odds Ratio |
|---|---|---|---|---|---|---|---|---|
| chr2:60668720 | rs12479062 | - | T>C | 156 | 80927 | 33.45 | 7.304e-09 | 1.635 |
| chr3:10296133 | rs2241309 | TATDN2 | G>A | 56 | 23130 | 26.86 | 2.185e-07 | 2.006 |
| chr15:75129584 | rs55973697 | ULK3 | A>C | 43 | 16282 | 26.25 | 2.992e-07 | 2.175 |
| chr18:56808506 | rs7241012 | SEC11C | G>A | 629 | 439309 | 25.31 | 4.873e-07 | 1.336 |
| chr13:42798856 | rs73172208 | DGKH | C>T | 30 | 9971 | 25.2 | 5.157e-07 | 2.457 |
| chr19:52992897 | rs10412040 | ZNF578 | G>A | 35 | 12996 | 22.68 | 1.912e-06 | 2.219 |
| chr7:37133095 | rs73688851 | ELMO1 | T>C | 38 | 14564 | 22.39 | 2.224e-06 | 2.143 |
| chr15:24159118 | rs74354920 | - | T>C | 39 | 14986 | 22.2 | 2.455e-06 | 2.118 |
| chr9:32248858 | rs1411871 | - | C>T | 63 | 28531 | 22.08 | 2.61e-06 | 1.822 |
| chr16:25606012 | rs117257865 | - | G>A | 49 | 20674 | 21.93 | 2.831e-06 | 1.957 |
| chr1:205637659 | rs57021717 | SLC45A3 | T>C | 38 | 14775 | 21.36 | 3.804e-06 | 2.107 |
| chr2:64709055 | rs6744703 | - | G>T | 116 | 62104 | 21.25 | 4.032e-06 | 1.566 |
| chr12:30440377 | rs2564532 | - | T>C | 213 | 128123 | 21.15 | 4.253e-06 | 1.415 |
| chr20:49324552 | rs868847 | - | A>G | 244 | 150870 | 20.45 | 6.119e-06 | 1.381 |
| chr4:35195126 | rs76413854 | - | T>C | 74 | 35874 | 20.35 | 6.465e-06 | 1.708 |
| chr10:8668216 | rs1325866 | - | A>G | 77 | 37762 | 20.16 | 7.112e-06 | 1.688 |
| chr2:231492412 | rs74197595 | - | T>G | 220 | 134871 | 19.22 | 1.168e-05 | 1.385 |
| chr3:10258579 | rs11465901 | IRAK2 | C>T | 34 | 13205 | 19.19 | 1.183e-05 | 2.108 |
| chr2:144036057 | rs116352959 | ARHGAP15 | A>G | 102 | 54469 | 18.62 | 1.597e-05 | 1.558 |
| chr5:165182242 | rs17052796 | - | C>T | 74 | 36678 | 18.62 | 1.599e-05 | 1.67 |
| chr2:60668720 | rs12479062 | - | T>C | 133 | 66653 | 34.22 | 4.927e-09 | 1.706 |
| chr15:75129584 | rs55973697 | ULK3 | A>C | 43 | 16147 | 27.59 | 1.503e-07 | 2.218 |
| chr13:42798856 | rs73172208 | DGKH | C>T | 30 | 9771 | 27.04 | 1.989e-07 | 2.534 |
| chr16:25606012 | rs117257865 | - | G>A | 49 | 20267 | 24.07 | 9.295e-07 | 2.02 |
| chr4:35195126 | rs76413854 | - | T>C | 74 | 35161 | 22.86 | 1.74e-06 | 1.765 |
| chr3:10258579 | rs11465901 | IRAK2 | C>T | 28 | 9579 | 22.57 | 2.029e-06 | 2.415 |
| chr15:24159118 | rs74354920 | - | T>C | 38 | 14589 | 22.37 | 2.247e-06 | 2.145 |
| chr19:52992897 | rs10412040 | ZNF578 | G>A | 33 | 12213 | 22.15 | 2.528e-06 | 2.249 |
| chr2:144036057 | rs116352959 | ARHGAP15 | A>G | 101 | 52803 | 21.35 | 3.836e-06 | 1.612 |
| chr1:205637659 | rs57021717 | SLC45A3 | T>C | 32 | 11929 | 20.72 | 5.319e-06 | 2.217 |
| chr19:53187079 | rs12052126 | ZNF83 | C>T | 188 | 112717 | 20.49 | 5.997e-06 | 1.433 |
| chr12:20233284 | rs78973055 | - | A>C | 27 | 9627 | 19.69 | 9.091e-06 | 2.318 |
| chr2:60587805 | rs138977534 | - | C>T | 47 | 20380 | 19.6 | 9.528e-06 | 1.914 |
| chr9:88847177 | rs74521757 | C9orf153 | C>T | 42 | 17946 | 18.65 | 1.567e-05 | 1.95 |
| chr3:49689642 | rs150021639 | BSN | C>T | 39 | 16186 | 18.63 | 1.586e-05 | 1.995 |
| chr4:58474613 | rs78413219 | - | G>C | 40 | 16752 | 18.63 | 1.588e-05 | 1.979 |
| chr23:122326318 | rs4825836 | GRIA3 | C>T | 245 | 168550 | 18.53 | 1.669e-05 | 1.388 |
| chr4:182231318 | rs10520474 | - | A>G | 120 | 67170 | 18.43 | 1.761e-05 | 1.51 |
| chr18:56808506 | rs7241012 | SEC11C | G>A | 571 | 408818 | 18.39 | 1.801e-05 | 1.291 |
| chr2:222476908 | rs76740534 | - | C>T | 88 | 46086 | 18.31 | 1.875e-05 | 1.602 |
Associated Phenotypes ⓘ
| ID | Name | Top Correlation |
|---|---|---|
| HP: 0006532 | Recurrent pneumonia | 1/20 |
| HP: 0025018 | Abnormal capillary physiology | 7/20 |
| HP: 0030005 | Capillary leak | 6/20 |