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ICD-10
HPO
Compare GWAS
Super Class
Arthrosis, unspecified
Sub Class
Arthrosis, unspecified (Hand)
M19.94
Case/Control GWAS
ⓘ
Links
Sex Split
Interactive Plot
Statistics
Case
Control
1713
458492
Top SNP Information
Show Table
Location
SNP
Gene
Ref>Alt
Alt in Case
Alt in Control
Chi-square
P-value
Odds Ratio
chr2:66725070
rs12995572
MEIS1
G>C
38
27113
37.93
7.328e-10
0.3802
chr15:48392165
rs1834640
-
A>G
51
31573
36.41
1.602e-09
0.437
chr15:29223282
rs8026324
APBA2
T>A
79
41597
35.82
2.163e-09
0.5121
chr1:159174683
rs2814778
ACKR1
T>C
21
19356
35.14
3.069e-09
0.295
chr15:48426484
rs1426654
SLC24A5
A>G
42
27484
34.33
4.659e-09
0.4142
chr8:145639681
rs1871534
SLC39A4
G>C
19
18126
33.86
5.928e-09
0.285
chr5:147671850
rs7724380
-
G>A
24
20159
33.65
6.601e-09
0.3236
chr4:52984391
rs6554227
-
G>A
28
21785
33.54
6.973e-09
0.3497
chr17:58508582
rs8071181
C17orf64
G>A
13
15404
33.47
7.248e-09
0.2295
chr5:33951693
rs16891982
SLC45A2
G>C
157
66904
32.53
1.176e-08
0.63
chr9:117110112
Affx-52344420
AKNA
T>TG
12
14567
32.05
1.504e-08
0.2243
chr17:58786625
rs2643103
BCAS3
G>A
23
19235
32.01
1.533e-08
0.3249
chr5:147863034
rs9325101
HTR4
A>G
17
16723
31.97
1.563e-08
0.2766
chr5:147666044
rs7707813
-
T>C
22
18741
31.71
1.791e-08
0.3192
chr19:42393286
rs717225
ARHGEF1
A>G
30
21913
31.39
2.115e-08
0.3726
chr3:188327555
rs7645635
LPP
T>C
12
14364
31.26
2.262e-08
0.2279
chr6:136480972
rs9483910
PDE7B
C>T
29
21343
31.03
2.547e-08
0.3688
chr1:245520118
rs4256853
KIF26B
T>C
32
22510
30.98
2.613e-08
0.3857
chr6:37328215
Affx-28571852
RNF8
C>CT
24
19292
30.82
2.826e-08
0.3382
chr5:33958959
rs28777
SLC45A2
A>C
129
56866
30.74
2.956e-08
0.6109
Associated Phenotypes
ⓘ
Shared SNP phenotypes
No shared SNP phenotypes
ID
Name
Top Correlation
HP: 0000118
Phenotypic abnormality
3/20
HP: 0000924
Abnormality of the skeletal system
2/20
HP: 0000940
Abnormal diaphysis morphology
2/20
HP: 0001155
Abnormality of the hand
8/20
HP: 0001167
Abnormality of finger
7/20
HP: 0001191
Abnormality of the carpal bones
6/20
HP: 0001367
Abnormal joint morphology
3/20
HP: 0001369
Arthritis
4/20
HP: 0001760
Abnormality of the foot
4/20
HP: 0001832
Abnormal metatarsal morphology
7/20
HP: 0001850
Abnormality of the tarsal bones
5/20
HP: 0001939
Abnormality of metabolism/homeostasis
3/20
HP: 0001964
Aplasia/Hypoplasia of metatarsal bones
8/20
HP: 0002813
Abnormality of limb bone morphology
4/20
HP: 0002814
Abnormality of the lower limb
4/20
HP: 0002817
Abnormality of the upper limb
5/20
HP: 0002823
Abnormality of femur morphology
2/20
HP: 0002979
Bowing of the legs
2/20
HP: 0002981
Abnormality of the calf
3/20
HP: 0002991
Abnormality of fibula morphology
5/20
HP: 0003019
Abnormality of the wrist
6/20
HP: 0003026
Short long bone
4/20
HP: 0003028
Abnormality of the ankles
3/20
HP: 0003037
Enlarged joints
4/20
HP: 0003330
Abnormal bone structure
2/20
HP: 0003366
Abnormality of the femoral neck or head region
3/20
HP: 0003368
Abnormality of the femoral head
2/20
HP: 0003649
Abnormality of glycoside metabolism
7/20
HP: 0003994
Dislocated wrist
7/20
HP: 0004248
Abnormality of the lunate bone
7/20
HP: 0004342
Abnormality of galactoside metabolism
7/20
HP: 0005262
Abnormality of the synovia
4/20
HP: 0005682
Talocalcaneal synostosis
5/20
HP: 0005918
Abnormal finger phalanx morphology
6/20
HP: 0005922
Abnormal hand morphology
8/20
HP: 0006247
Enlarged interphalangeal joints
5/20
HP: 0006261
Abnormal phalangeal joint morphology of the hand
4/20
HP: 0006487
Bowing of the long bones
2/20
HP: 0006493
Aplasia/hypoplasia involving bones of the lower limbs
3/20
HP: 0006494
Aplasia/Hypoplasia involving bones of the feet
9/20
HP: 0006499
Abnormality of femoral epiphysis
2/20
HP: 0006500
Abnormality of lower limb epiphysis morphology
2/20
HP: 0006504
obsolete Anomaly of the limb diaphyses morphology
2/20
HP: 0006505
Abnormality of limb epiphysis morphology
2/20
HP: 0008166
Decreased beta-galactosidase activity
7/20
HP: 0008368
Tarsal synostosis
5/20
HP: 0008812
Flattened femoral head
6/20
HP: 0009115
Aplasia/hypoplasia involving the skeleton
3/20
HP: 0009138
Synostosis involving bones of the lower limbs
5/20
HP: 0009140
Synostosis involving bones of the feet
5/20
HP: 0009810
Abnormality of upper limb joint
3/20
HP: 0009815
Aplasia/hypoplasia of the extremities
3/20
HP: 0010054
Abnormality of the first metatarsal bone
8/20
HP: 0010105
Short first metatarsal
8/20
HP: 0010502
Fibular bowing
7/20
HP: 0010743
Short metatarsal
8/20
HP: 0010889
Morbus Kienboeck
6/20
HP: 0011297
Abnormal digit morphology
6/20
HP: 0011314
Abnormality of long bone morphology
1/20
HP: 0011729
Abnormality of joint mobility
5/20
HP: 0011842
Abnormality of skeletal morphology
2/20
HP: 0011844
Abnormal appendicular skeleton morphology
3/20
HP: 0012313
Heberden's node
5/20
HP: 0012379
Abnormal enzyme/coenzyme activity
5/20
HP: 0012531
Pain
1/20
HP: 0025142
Constitutional symptom
2/20
HP: 0030310
Upper extremity joint dislocation
2/20
HP: 0040064
Abnormality of limbs
3/20
HP: 0040068
Abnormality of limb bone
4/20
HP: 0040069
Abnormal lower limb bone morphology
4/20
HP: 0040070
Abnormal upper limb bone morphology
3/20
HP: 0045060
Aplasia/hypoplasia involving bones of the extremities
3/20
HP: 0100240
Synostosis of joints
5/20
HP: 0100266
Synostosis of carpals/tarsals
5/20
HP: 0100491
Abnormality of lower limb joint
5/20
ID
Name
Top Correlation
HP: 0001373
Joint dislocation
0/20
HP: 0002829
Arthralgia
0/20
HP: 0005059
Arthralgia/arthritis
0/20
HP: 0005930
Abnormality of epiphysis morphology
0/20
HP: 0010885
Avascular necrosis
0/20
HP: 0011843
Abnormality of skeletal physiology
0/20
HP: 0100323
Juvenile aseptic necrosis
0/20