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ICD-10
HPO
Compare GWAS
Super Class
Arthrosis, unspecified
Sub Class
Arthrosis, unspecified (Ankle and foot)
M19.97
Case/Control GWAS
ⓘ
Links
Sex Split
Interactive Plot
Statistics
Case
Control
3355
456850
Top SNP Information
Show Table
Location
SNP
Gene
Ref>Alt
Alt in Case
Alt in Control
Chi-square
P-value
Odds Ratio
chr5:33951693
rs16891982
SLC45A2
G>C
332
66729
47.99
4.292e-12
0.6783
chr5:33958959
rs28777
SLC45A2
A>C
274
56721
45.7
1.381e-11
0.6605
chr15:48426484
rs1426654
SLC24A5
A>G
105
27421
43.73
3.772e-11
0.527
chr6:162594941
rs871387
PRKN
T>C
187
39331
33.07
8.901e-09
0.6543
chr5:33955326
rs35390
SLC45A2
A>C
200
40949
31.01
2.57e-08
0.6717
chr5:33955673
rs35391
SLC45A2
C>T
200
40782
30.36
3.582e-08
0.6745
chr14:106022537
rs28833814
-
A>G
183
37814
29.54
5.478e-08
0.6667
chr17:77545900
rs57526497
-
C>A
364
66848
29.45
5.736e-08
0.7468
chr5:142484447
rs2398612
ARHGAP26
T>C
521
91105
29.12
6.81e-08
0.782
chr15:48392165
rs1834640
-
A>G
146
31478
29.07
6.964e-08
0.6387
chr6:75853674
rs9447452
COL12A1
C>A
45
13615
28.67
8.602e-08
0.4575
chr20:2315543
rs6132532
AL121899.2
A>G
255
49279
28.58
9.012e-08
0.7115
chr1:1155757
rs4970422
SDF4
C>T
206
41207
28.39
9.938e-08
0.6869
chr5:33951116
rs35397
SLC45A2
T>G
514
89597
28.05
1.183e-07
0.7843
chr14:75017379
rs1992304
LTBP2
C>T
170
35256
27.93
1.256e-07
0.6646
chr1:55462380
rs9887913
-
T>C
149
31538
27.05
1.987e-07
0.6515
chr17:75396461
rs312860
SEPTIN9
A>G
1112
178330
26.58
2.531e-07
0.8445
chr15:40995335
rs4924496
RAD51
C>T
3090
399071
26.38
2.811e-07
1.134
chr6:3189788
rs4327734
-
C>T
52
14503
26.31
2.906e-07
0.4962
chr2:171380643
rs34020565
MYO3B
T>G
110
24749
26.15
3.151e-07
0.614
Associated Phenotypes
ⓘ
Shared SNP phenotypes
No shared SNP phenotypes
ID
Name
Top Correlation
HP: 0000118
Phenotypic abnormality
3/20
HP: 0000924
Abnormality of the skeletal system
2/20
HP: 0000940
Abnormal diaphysis morphology
3/20
HP: 0001155
Abnormality of the hand
6/20
HP: 0001167
Abnormality of finger
6/20
HP: 0001191
Abnormality of the carpal bones
7/20
HP: 0001367
Abnormal joint morphology
4/20
HP: 0001369
Arthritis
8/20
HP: 0001760
Abnormality of the foot
5/20
HP: 0001832
Abnormal metatarsal morphology
8/20
HP: 0001850
Abnormality of the tarsal bones
6/20
HP: 0001964
Aplasia/Hypoplasia of metatarsal bones
6/20
HP: 0002813
Abnormality of limb bone morphology
6/20
HP: 0002814
Abnormality of the lower limb
8/20
HP: 0002817
Abnormality of the upper limb
7/20
HP: 0002823
Abnormality of femur morphology
5/20
HP: 0002979
Bowing of the legs
3/20
HP: 0002981
Abnormality of the calf
4/20
HP: 0002991
Abnormality of fibula morphology
6/20
HP: 0003019
Abnormality of the wrist
7/20
HP: 0003026
Short long bone
9/20
HP: 0003028
Abnormality of the ankles
4/20
HP: 0003037
Enlarged joints
8/20
HP: 0003330
Abnormal bone structure
2/20
HP: 0003366
Abnormality of the femoral neck or head region
6/20
HP: 0003368
Abnormality of the femoral head
5/20
HP: 0003649
Abnormality of glycoside metabolism
5/20
HP: 0003994
Dislocated wrist
5/20
HP: 0004248
Abnormality of the lunate bone
5/20
HP: 0004342
Abnormality of galactoside metabolism
5/20
HP: 0005262
Abnormality of the synovia
8/20
HP: 0005682
Talocalcaneal synostosis
5/20
HP: 0005918
Abnormal finger phalanx morphology
9/20
HP: 0005922
Abnormal hand morphology
6/20
HP: 0006247
Enlarged interphalangeal joints
9/20
HP: 0006261
Abnormal phalangeal joint morphology of the hand
8/20
HP: 0006487
Bowing of the long bones
3/20
HP: 0006493
Aplasia/hypoplasia involving bones of the lower limbs
8/20
HP: 0006494
Aplasia/Hypoplasia involving bones of the feet
6/20
HP: 0006499
Abnormality of femoral epiphysis
5/20
HP: 0006500
Abnormality of lower limb epiphysis morphology
5/20
HP: 0006504
obsolete Anomaly of the limb diaphyses morphology
2/20
HP: 0006505
Abnormality of limb epiphysis morphology
4/20
HP: 0008166
Decreased beta-galactosidase activity
5/20
HP: 0008368
Tarsal synostosis
5/20
HP: 0008812
Flattened femoral head
6/20
HP: 0009115
Aplasia/hypoplasia involving the skeleton
4/20
HP: 0009138
Synostosis involving bones of the lower limbs
5/20
HP: 0009140
Synostosis involving bones of the feet
5/20
HP: 0009810
Abnormality of upper limb joint
7/20
HP: 0009815
Aplasia/hypoplasia of the extremities
6/20
HP: 0010054
Abnormality of the first metatarsal bone
6/20
HP: 0010105
Short first metatarsal
6/20
HP: 0010502
Fibular bowing
5/20
HP: 0010743
Short metatarsal
6/20
HP: 0010889
Morbus Kienboeck
5/20
HP: 0011297
Abnormal digit morphology
9/20
HP: 0011314
Abnormality of long bone morphology
1/20
HP: 0011729
Abnormality of joint mobility
8/20
HP: 0011842
Abnormality of skeletal morphology
2/20
HP: 0011844
Abnormal appendicular skeleton morphology
5/20
HP: 0012313
Heberden's node
9/20
HP: 0012531
Pain
1/20
HP: 0025142
Constitutional symptom
2/20
HP: 0030310
Upper extremity joint dislocation
2/20
HP: 0040064
Abnormality of limbs
7/20
HP: 0040068
Abnormality of limb bone
6/20
HP: 0040069
Abnormal lower limb bone morphology
8/20
HP: 0040070
Abnormal upper limb bone morphology
5/20
HP: 0045060
Aplasia/hypoplasia involving bones of the extremities
6/20
HP: 0100240
Synostosis of joints
6/20
HP: 0100266
Synostosis of carpals/tarsals
5/20
HP: 0100491
Abnormality of lower limb joint
8/20
ID
Name
Top Correlation
HP: 0001373
Joint dislocation
0/20
HP: 0001939
Abnormality of metabolism/homeostasis
0/20
HP: 0002829
Arthralgia
0/20
HP: 0005059
Arthralgia/arthritis
0/20
HP: 0005930
Abnormality of epiphysis morphology
0/20
HP: 0010885
Avascular necrosis
0/20
HP: 0011843
Abnormality of skeletal physiology
0/20
HP: 0012379
Abnormal enzyme/coenzyme activity
0/20
HP: 0100323
Juvenile aseptic necrosis
0/20