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ICD-10
HPO
Compare GWAS
Super Class
Symptoms and signs involving the circulatory and respiratory systems
Sub Class
Pain in throat
Chest pain on breathing
Precordial pain
Other chest pain
Chest pain, unspecified
Pain in throat and chest
R07
Female
ⓘ
Male
ⓘ
Links
Ignore Sex
Interactive Plot
Statistics
Female Case
Female Control
% Female
20107
229750
51%
Male Case
Male Control
% Male
19605
190732
49%
Top SNP Information
Show Female
Show Male
Location
SNP
Gene
Ref>Alt
Alt in Case
Alt in Control
Chi-square
P-value
Odds ratio
chr5:33951693
rs16891982
SLC45A2
G>C
3761
32446
236.1
2.828e-53
1.318
chr5:33958959
rs28777
SLC45A2
A>C
3238
27602
220.0
9.148e-50
1.33
chr2:66725070
rs12995572
MEIS1
G>C
1690
13473
174.6
7.187e-40
1.413
chr2:56909573
rs6732353
-
C>T
1001
7446
165.0
9.16e-38
1.544
chr16:28995057
rs11859822
SPNS1
T>C
1778
14464
161.3
5.969e-37
1.383
chr6:136480972
rs9483910
PDE7B
C>T
1380
10761
160.8
7.712e-37
1.442
chr10:124948232
rs73362778
-
G>A
866
6344
152.7
4.563e-35
1.566
chr16:28954860
rs7203982
-
T>C
1756
14393
151.7
7.355e-35
1.372
chr6:4545509
rs1119984
-
C>G
1103
8527
150.9
1.076e-34
1.486
chr9:129562274
rs78594581
-
C>T
932
6823
148.9
2.968e-34
1.533
chr1:15286096
rs12068752
-
A>G
890
6603
148.4
3.969e-34
1.547
chr6:136516257
rs7753890
PDE7B
T>C
1946
16289
147.9
5.107e-34
1.346
chr11:88690518
rs672144
-
C>G
1047
8056
146.9
8.088e-34
1.493
chr19:42393286
rs717225
ARHGEF1
A>G
1390
11029
146.3
1.107e-33
1.416
chr8:145639681
rs1871534
SLC39A4
G>C
1194
9226
145.2
1.907e-33
1.453
chr1:159174683
rs2814778
ACKR1
T>C
1251
9786
142.3
8.283e-33
1.435
chr6:136511472
rs3799396
PDE7B
A>G
1944
16358
142.1
9.477e-33
1.338
chr10:108754043
rs7919051
-
C>T
1022
7891
140.7
1.882e-32
1.487
chr9:21931609
rs7868374
-
A>G
1043
8100
140.0
2.61e-32
1.48
chr16:130853
rs3176406
-
A>G
857
6389
139.7
3.108e-32
1.539
Location
SNP
Gene
Ref>Alt
Alt in Case
Alt in Control
Chi-square
P-value
Odds ratio
chr5:33951693
rs16891982
SLC45A2
G>C
3537
27314
145.9
1.352e-33
1.252
chr5:33958959
rs28777
SLC45A2
A>C
2982
23170
115.0
7.725e-27
1.241
chr5:33955326
rs35390
SLC45A2
A>C
2210
16863
99.26
2.218e-23
1.26
chr5:33955673
rs35391
SLC45A2
C>T
2200
16788
98.78
2.82e-23
1.26
chr5:33951116
rs35397
SLC45A2
T>G
4466
36963
84.9
3.139e-20
1.167
chr11:61095368
rs7397033
DDB1
T>C
822
5921
57.01
4.34e-14
1.327
chr17:9586811
rs73975789
USP43
A>G
764
5458
55.42
9.747e-14
1.335
chr12:118007458
rs17618513
KSR2
G>A
597
4131
53.76
2.265e-13
1.38
chr2:152848504
rs4146377
CACNB4
C>T
1220
9326
53.06
3.239e-13
1.252
chr17:5883926
rs75176779
AC007846.2
A>G
815
5935
52.24
4.915e-13
1.312
chr2:210564805
rs13424278
MAP2
A>G
954
7097
51.85
5.978e-13
1.285
chr4:188970959
rs61385796
-
C>T
767
5546
51.56
6.932e-13
1.321
chr15:28513364
rs916977
HERC2
C>T
7953
70047
51.16
8.523e-13
1.098
chr15:28530182
rs1667394
HERC2
T>C
8287
73229
49.22
2.286e-12
1.095
chr17:5865515
rs723656
AC007846.2
G>A
1879
15132
48.27
3.715e-12
1.19
chr2:210484445
rs2663644
MAP2
G>A
1078
8201
48.18
3.891e-12
1.255
chr15:28132043
rs2703970
OCA2
T>C
1753
14061
46.91
7.422e-12
1.194
chr15:28356859
rs1129038
HERC2
T>C
11505
103275
46.3
1.017e-11
1.081
chr13:73649397
rs4885064
KLF5
A>C
683
4944
45.63
1.428e-11
1.319
chr16:20367239
rs7204342
UMOD
G>T
1179
9130
45.32
1.671e-11
1.235
Associated Phenotypes
ⓘ
Shared SNP phenotype
No shared SNP phenotype
ID
Name
Top Correlation
HP: 0000118
Phenotypic abnormality
1/20
HP: 0000600
Abnormality of the pharynx
1/20
HP: 0000756
Agoraphobia
3/20
HP: 0000765
Abnormality of the thorax
1/20
HP: 0001627
Abnormal heart morphology
4/20
HP: 0001739
Abnormality of the nasopharynx
3/20
HP: 0001939
Abnormality of metabolism/homeostasis
2/20
HP: 0001962
Palpitations
18/20
HP: 0002205
Recurrent respiratory infections
1/20
HP: 0002788
Recurrent upper respiratory tract infections
3/20
HP: 0003115
Abnormal EKG
2/20
HP: 0003140
T-wave inversion in the right precordial leads
2/20
HP: 0005120
Abnormal cardiac atrium morphology
3/20
HP: 0011025
Abnormal cardiovascular system physiology
1/20
HP: 0011110
Tonsillitis
1/20
HP: 0011628
Congenital defect of the pericardium
7/20
HP: 0011629
Total absence of the pericardium
7/20
HP: 0011642
Abnormal coronary sinus morphology
3/20
HP: 0012249
Abnormal ST segment
5/20
HP: 0012250
ST segment depression
5/20
HP: 0012251
ST segment elevation
8/20
HP: 0012337
Abnormal homeostasis
13/20
HP: 0012735
Cough
2/20
HP: 0025015
Abnormal vascular morphology
2/20
HP: 0025143
Chills
5/20
HP: 0025323
Abnormal arterial physiology
5/20
HP: 0025439
Pharyngitis
1/20
HP: 0025496
Abnormal coronary artery physiology
7/20
HP: 0025497
Coronary artery spasm
7/20
HP: 0030766
Ear pain
3/20
HP: 0030846
Abnormality of venous physiology
1/20
HP: 0030847
Abnormal jugular venous pressure
2/20
HP: 0030848
Elevated jugular venous pressure
2/20
HP: 0031298
Coronary sinus enlargement
3/20
HP: 0031659
Fourth heart sound
2/20
HP: 0031690
Opportunistic infection
3/20
HP: 0032141
Precordial pain
1/20
HP: 0032249
Coccidioidomycosis
2/20
HP: 0100749
Chest pain
6/20
HP: 0100763
Abnormality of the lymphatic system
1/20
HP: 0100776
Recurrent pharyngitis
7/20
HP: 0100851
Abnormal emotion/affect behavior
3/20
HP: 0100852
Abnormal fear/anxiety-related behavior
2/20
HP: 0500015
Abnormal cardiac test
2/20
ID
Name
Top Correlation
HP: 0000152
Abnormality of head or neck
0/20
HP: 0000234
Abnormality of the head
0/20
HP: 0000271
Abnormality of the face
0/20
HP: 0000366
Abnormality of the nose
0/20
HP: 0000598
Abnormality of the ear
0/20
HP: 0000707
Abnormality of the nervous system
0/20
HP: 0000708
Behavioral abnormality
0/20
HP: 0000924
Abnormality of the skeletal system
0/20
HP: 0000969
Edema
0/20
HP: 0001608
Abnormality of the voice
0/20
HP: 0001609
Hoarse voice
0/20
HP: 0001626
Abnormality of the cardiovascular system
0/20
HP: 0001697
Abnormal pericardium morphology
0/20
HP: 0002012
Abnormality of the abdominal organs
0/20
HP: 0002086
Abnormality of the respiratory system
0/20
HP: 0002088
Abnormal lung morphology
0/20
HP: 0002105
Hemoptysis
0/20
HP: 0002597
Abnormality of the vasculature
0/20
HP: 0002715
Abnormality of the immune system
0/20
HP: 0002719
Recurrent infections
0/20
HP: 0002795
Functional respiratory abnormality
0/20
HP: 0003565
Elevated erythrocyte sedimentation rate
0/20
HP: 0005135
Abnormal T-wave
0/20
HP: 0009121
Abnormal axial skeleton morphology
0/20
HP: 0010872
T-wave inversion
0/20
HP: 0010978
Abnormality of immune system physiology
0/20
HP: 0011024
Abnormality of the gastrointestinal tract
0/20
HP: 0011032
Abnormality of fluid regulation
0/20
HP: 0011675
Arrhythmia
0/20
HP: 0011842
Abnormality of skeletal morphology
0/20
HP: 0011855
Pharyngeal edema
0/20
HP: 0011947
Respiratory tract infection
0/20
HP: 0012252
Abnormal respiratory system morphology
0/20
HP: 0012531
Pain
0/20
HP: 0012638
Abnormal nervous system physiology
0/20
HP: 0012719
Functional abnormality of the gastrointestinal tract
0/20
HP: 0020100
Unusual fungal infection
0/20
HP: 0025021
Abnormal erythrocyte sedimentation rate
0/20
HP: 0025031
Abnormality of the digestive system
0/20
HP: 0025032
Abnormality of digestive system physiology
0/20
HP: 0025033
Abnormality of digestive system morphology
0/20
HP: 0025142
Constitutional symptom
0/20
HP: 0030163
Abnormal vascular physiology
0/20
HP: 0030166
Night sweats
0/20
HP: 0030680
Abnormality of cardiovascular system morphology
0/20
HP: 0030956
Abnormality of cardiovascular system electrophysiology
0/20
HP: 0031245
Productive cough
0/20
HP: 0031416
Abnormal nasal mucus secretion
0/20
HP: 0031417
Rhinorrhea
0/20
HP: 0031466
Impairment in personality functioning
0/20
HP: 0031657
Abnormal heart sound
0/20
HP: 0031704
Abnormal ear physiology
0/20
HP: 0032016
Abnormal sputum
0/20
HP: 0032043
Odynophagia
0/20
HP: 0032101
Unusual infection
0/20
HP: 0032255
Opportunistic fungal infection
0/20
HP: 0100765
Abnormality of the tonsils
0/20